The research and improvement of drug quality have been highly valued by well-known pharmaceutical companies in various countries. The same medication may have variable impurity contents, bioavailability, and side effects depending on the drug's brand, generic, domestic origin, or importation. Its clinical safety and effectiveness are naturally different.
With rich experience in generic drug development, Our company provides professional consistency evaluation services to conduct drug consistency studies to improve and ensure the safety and efficacy of drugs. We have successfully completed a number of quality consistency evaluation cases and generic medication studies in the field of generic medicine quality consistency evaluation.
Service Overview
Our company offers specialized services aimed at determining the structure of biomolecules, such as proteins, nucleic acids and their complexes. From structure design, gene cloning and expression, custom protein production, protein characterization, crystal screening and optimization, X-ray diffraction data collection, and structure resolution, we provide a full range of services for protein expression and protein purification in effective expression systems. We also offer cells that express target proteins and recombinant proteins for functional tests.
In order to enable structure-based medication development, from the discovery of new targets through the determination of the final structure, our structural biology laboratory is outfitted with molecular cloning rooms and protein crystallography-based drug discovery and screening procedures. Our researchers have a great deal of experience resolving the structures of many different protein targets, including membrane proteins, molecular chaperones, kinases, and polymerases.
Research Capabilities
Protein Expression and Purification
We provide top-notch proteins for biophysical and structural research, high-throughput screening, and enzyme analysis. Prokaryotic, yeast, insect, and mammalian cell protein expression systems are some of the several types of systems we have available for the expression of proteins.
X-ray Based Crystal Structure Biology
We have examined a range of various protein targets, provided multiple eutectic structures, and satisfied crystallization needs by developing multiple constructs for specific gene-to-structure research.
Selenomethionine Media
We offer a complete line of selenomethionine media for IPTG-induced E. coli expression systems, production of selenomethionine-tagged proteins, and protein crystallography using multi-wavelength anomalous diffraction.
Generation of Stable Cell Lines
We have extensive experience in handling target genes including kinases, carboxylases, ion channels, GPCR, lipases, etc. Stable cells can be generated in different cellular backgrounds by using plasmid-mediated or lentivirus-mediated transfection.
Overall Solutions
| Project Name | Structural Biology Services |
| Service Options | |
| Deliverables | Original images and raw data.
A complete experimental report, including experimental materials, experimental procedures, and experimental results. |
| Cycle | Decide according to your needs. |
If you are looking for smarter, higher quality solutions that incorporate best practices, please feel free to contact us.
Related Services
It should be noted that our service is only used for research, not for clinical use.
