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Hit Identification

In the field of drug discovery, a "hit" refers to a compound in the early stages of research that has been discovered to interact with a specific biological target. It is the raw material used to design drugs that can potentially be used in medical treatment to combat diseases. Hit identification signifies the procedure of pinpointing these compounds, and its essence is to select potential candidate compounds by screening vast compound libraries against a specific biological target. Hit identification is an early but crucial phase in the drug discovery process, and acts as a pivotal cornerstone in pharmaceutical research, shaping the trajectory of subsequent steps in the drug discovery process. Our company is renowned for its all-inclusive services for hit identification. Through our multifaceted strategies, we can provide a faster identification of biologically potent hits for our customers from all over the world.

State-of-the-art Methods for Hit Identification

At our company, we leverage diverse, cutting-edge methods to drive the successful identification of hits. Our approaches include high-throughput screening, fragment-based drug discovery, virtual screening, phenotypic screening, and DNA-Encoded library amongst others.

High-throughput Screening (HTS): HTS is a widely used process by which thousands of unique chemical and biological entities are screened simultaneously to identify active compounds, antibodies, or genes pertinent to a specific biochemical pathway. HTS proves to be advantageous with its ability in identifying active compounds in the initial screening process itself, ensuring time and cost-effectiveness. This approach allows us to test large numbers of compounds quickly, thus drastically increasing the possibility of identifying potential hits. With this method, we effortlessly screen thousands of compounds in biological assays.

Fragment-based Drug Discovery (FBDD): FBDD approach involves the identification of fragment molecules that bind to the protein targets. These fragment hits typically possess lower molecular weights, thereby ensuring a larger area of chemical space coverage. FBDD has been highly successful in the identification of novel compounds with unique binding sites not found by traditional HTS. Using our FBDD approach, it can identify small chemical fragments, which, although they may have a relatively low affinity, may lead to novel mechanisms of action.

Virtual Screening (VS): Virtual screening or in-silico screening is a computational method employed to search libraries of small molecules in order to find those structures that are likely to bind to a drug target, typically protein receptor or enzyme. In this regard, we provide two types of this service: structure-based virtual screening, which creates a model of a receptor and uses it to screen a database of compounds, and ligand-based virtual screening, which screens the database of compounds using a model derived from known ligands.

Phenotypic Screening: Phenotypic screening is a powerful and innovative way to identify new first-in-class drugs with novel mechanisms of action. Phenotypic assays measure cellular behaviors, allowing the identification of active compounds without any prior knowledge of their targets. By using our phenotypic screening approach, thus, facilitates the identification of compounds that may modulate multiple targets simultaneously and exert synergistic effects.

DNA-Encoded Library (DEL): DEL is an emerging technology that allows the synthesis and screening of millions to billions of chemical compounds. After screening, the "hits" can be easily identified by sequencing the attached DNA. Our libraries are maximally diverse, which can generate hit compounds quickly and rapidly jump-start your medicinal chemistry programs.

Why Choose Us?

Expertise

Our team of scientists has extensive experience and are well-equipped with the latest technology. In addition, we apply our expert knowledge to optimize the identified hits' factors such as pharmacodynamics, pharmacokinetics and toxicology.

Transparency

We provide detailed reports of our works, including the experiment details and all associated data. We stress on transparency with our clients and aim for their utmost satisfaction.

Support

We offer full support during the entire process of hit identification, backed by excellent customer service.

Tailor-made Service

For every project, our services are tailor-made to ensure the best results. Every project is unique at our company.

Hit identification is an indispensable phase in the drug discovery journey. With our advanced technology and expertise, we continue to identify and develop novel drug candidates that aim to make a significant contribution to human health. For more details, please feel free to contact us.

It should be noted that our service is only used for research, not for clinical use.

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