Target Identification and Validation

In the field of drug discovery and development, a 'target' refers to the naturally existing cellular or molecular structure (such as protein, gene, RNA, nucleic acid) involved in the pathology of interest that the drug-in-development is meant to act on. Identifying and validating these targets is crucial and is also the first step in drug discovery and development. Target identification involves identifying the proteins or genes that are crucial for a particular disease or biological process. Target validation ensures the selected target's involvement in the disease state and evaluates whether interaction of a drug with the target elicits the desired therapeutic effect. Identifying and validating the right target can significantly increase the success rate of drug development and improve the chances of developing effective treatments for various diseases. Our company offers quality target identification and validation services, and performs comprehensive suite of solutions integrates state-of-the-art technologies, bioinformatics and biomedical expertise to ensure efficient identification and precise validation of targets.

Techniques for Target Identification and Validation

Rich experience of drug discovery has equipped us with reputable techniques for target identification and validation. We can complete target identification and validation through the following technical platforms (including but not limited to):

• Phenotypic Screening: Our company offers a variety of phenotypic assays suitable for the study of HTS and mechanisms of action, in which we use complex cell models to simulate disease. It has great potential to identify truly novel targets.
• Genome-Wide Association Studies (GWAS): Our company utilizes statistical associations of certain gene variants in affected individuals compared to controls to identify potential targets.
• In Vitro Genetic Validation Techniques: In this regard, our company uses techniques such as RNA interference (RNAi) (such as siRNA or shRNA) to reduce the expression levels of specific genes. They can illuminate genetic factors associated with disease and highlight potential targets.
• Proteomics: We can analyze the entire set of proteins expressed in a cell, tissue, or organism to identify potential drug targets that are involved in disease pathways and validate their importance in disease progression.
• Bioinformatics and Computational Biology: We deal with the computational prediction of drug targets based on various bioinformatics databases and tools. by this method, structural and functional genomics data can be utilized to predict and validate potential therapeutic targets.

At our company, these are just some of the myriad techniques employed in target identification and validation. Our flexible and efficient approach enables us to identify robust targets, validate their relevance to the human disease, and effectively translate these findings into drug discovery programs. With our platform and professional team of scientists, we are ensuring the demands of our client's academic or industrial projects are met in a timely and cost-effective manner.

Why Choose Us?

Interdisciplinary Expertise

Our team consists of experts versed in biochemistry, molecular and cell biology, and structural biology. This not only allows for a rigorous assessment but also the intellectual flexibility to adapt to changing dynamics within the projects.

Technical Proficiency

Our company has the comprehensive capabilities to conduct genomic, proteomic, and phenotypic analyses. The deployment of advanced technologies like next-generation sequencing, and mass spectrometry techniques is a competitive edge in discovery research.

Robust Analytics

Our bioinformatics team can efficiently process and analyze the vast data often associated with discovery research projects. This facilitates the rapid progression from initial biological validation to drug discovery.

Customized Solutions

We understand that each discovery project has unique aspects, hence we tailor our approach to align with the project's unique objectives, making our company an ideal partner for target identification and validation.

It should be noted that our service is only used for research, not for clinical use.