Toxicokinetics (TK) is the generation of pharmacokinetic data as part of a non-clinical toxicology study. The link between a compound's concentration or dose and its potential toxicity is measured by TK. For all sorts of toxicity investigations, Our company has experience and skill in the design of sophisticated non-clinical research. Depending on the scientific question that has to be addressed, we may offer a range of well-designed TK study services that use a variety of approaches and methodologies.
Service Overview
Our company has complete pharmacokinetic (PK), TK, and analytical study facilities and equipment, as well as internationally approved toxicology research capabilities to support mixed reporting programs in numerous nations.
We can conduct TK studies using cutting-edge equipment on a variety of animals, including mice, rats, rabbits, dogs, pigs, and non-human primates. We can offer high-quality TK study services, including different administration methods, toxicity study types, and challenging non-clinical study designs, thanks to our years of experience in the field.
We can quantify compounds in a range of biological matrices, including but not limited to blood, plasma, serum, urine, and tissue, using our cutting-edge LC/MS technology. Test compound concentrations in body fluids and tissues can be measured based on your unique needs. To aid in the development of your project, we may also create or transfer analytical procedures for our customers.
Equipment:
- LC-MS/MS
- ICP-OES
- UV/Vis Spectrophotometer
- Validated Computer System
- HPLC: UPLC System-UV, ELSD Detector
- Enzyme-Linked Immunosorbent Assay (ELISA) System
Research Capabilities
The basic pharmacokinetic parameters of a drug can be obtained through PK, and it can also explain the mechanisms and traits of drug absorption, distribution, metabolism, and excretion. One of the key components of drug toxicology studies is the PK, which is primarily used to determine the extent and duration of the subject's systemic exposure at various dose levels during toxicity tests and to forecast the possible danger of the subject when exposed to people.
A PK test focuses on interpreting the results of toxicity tests and forecasting human safety, rather than merely defining the fundamental pharmacokinetic properties of medicine.
Fig 1. A simple, efficient, sensitive and stable LC-MS/MS method was used to determine RLA in rats, using deu-lipoic acid as an internal standard. (Zhou W, et al. 2022)
Our study capabilities include, but are not limited to:
| In Vitro ADME Studies | Metabolic stability. Metabolite identification. Plasma protein binding assay. CYPase inhibition studies. CYPase induction studies. Transporter substrate and inhibition evaluation. Enzyme phenotype analysis. |
| In Vivo PK Studies | Solute and formulation screening. Bridging experiments between preclinical and clinical formulations. Bioavailability. Tissue distribution. Biliary, urinary and fecal excretion. BE studies. PK/PD studies. Metabolite identification of in vivo samples. |
| In Vivo TK Studies | TK/PD/TOX analysis. Sex difference/dose correlation/accumulation analysis. Active ingredient/prodrug/metabolite monitoring. Metabolite identification of TK samples. Immunogenicity analysis. |
Overall Solutions
| Project Name | Toxicokinetics Study Service |
| Service Details | - Knowledge Support for PK Research
- Independent investigative TK studies
- GLP and non-GLP TK analysis
- Study design, including dose selection, frequency and sample collection
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| Deliverables | Within agreed time, we will provide the summary to experiment data and conclusions, as well as a final experiment report. |
| Cycle | Decide according to your needs. |
Our company is dedicated to being a helpful partner in the development of your innovative medicines. We would be delighted to collaborate with you to create your drug discovery program. Our knowledgeable scientists will collaborate closely with you to offer a wide range of services.
For more information, please feel free to contact us.
Reference
- Zhou W, et al. (2022). "A Quantitative LC-MS/MS Method for the Simultaneous Determination of the Presence of R-α-lipoic Acid and S-α-lipoic Acid After Protein Precipitation in Rat Plasma and its Application in a Toxicokinetic Study." Safety Pharmacology. 18(1): 101-110.
Related Services
It should be noted that our service is only used for research, not for clinical use.
