Insoluble Drug Solubilization Technology Platform

Our company has developed a cutting-edge insoluble drug solubilization technology platform that addresses the problem of poor solubility faced by many drugs. Our platform has established a variety of mature drug solubilization technologies and successfully delivered related projects. Through our platform, we can help our customers optimize the performance of their drug candidates, leading to improved clinical outcomes.

Our Insoluble Drug Solubilization Technology Platform

Our insoluble drug solubilization technology platform offers a range of services. We can assist in formulating insoluble drugs into soluble formulations for various dosage forms such as tablets, capsules, injections, and suspensions. By solubilizing insoluble drugs, we can enhance their bioavailability, thereby increasing the therapeutic efficacy of the drug. We can also assist in the development of novel drug delivery systems that improve the delivery of insoluble drugs to the target site of action. In addition, we can provide customized solutions based on the specific characteristics and requirements of the insoluble drug in question.

Our Insoluble Drug Solubilization Technologies

We use a variety of technologies to dissolve insoluble drugs, including:

• Solid dispersion technology. Solid dispersion technology involves dispersing insoluble drugs in a solid matrix, such as a polymer or a lipid, to increase their solubility. Solid dispersions can improve the dissolution rate and bioavailability of poorly soluble drugs.
• Cyclodextrin inclusion technology. Cyclodextrin inclusion technology is a method of incorporating hydrophobic drugs or molecules into the interior of cyclodextrin molecules to form inclusion complexes. Cyclodextrins are cyclic oligosaccharides that can form inclusion complexes with insoluble drugs, increasing their solubility in water.

• Hot melt extrusion (HME) technology. HME technology is a widely used pharmaceutical manufacturing process that is particularly effective in improving drug dissolution rates and promoting drug release. The high shear forces generated during hot melt extrusion process contribute to reducing the particle size of the drug and dispersing it uniformly throughout the polymer matrix. This leads to increased surface area for drug dissolution upon administration, resulting in enhanced solubility and bioavailability.
• Spray drying technology. Spray drying is a technique utilized for solubilization of insoluble drugs where the drug is dissolved or dispersed in a solvent and then atomized into fine droplets within a hot drying gas stream. As these droplets evaporate, the drug particles are formed and collected as a dried powder. Spray drying technology can significantly increase the dissolution rate of poorly soluble drugs and improve bioavailability in the body.
• Synthetic water-soluble precursor technology. The water-soluble precursor can transport the active drugs to their target site, where they undergo conversion into the active form through various metabolic processes or chemical reactions within the body. This precursor compound acts as a prodrug or drug conjugate that readily dissolves in water, overcoming the insolubility issues associated with certain drugs.

It should be noted that our service is only used for research, not for clinical use.