Carbapenem Series Products

Introduction

Carbapenems are a class of β-lactam antibiotics with the structure of a beta-lactam ring fused to a five-membered ring. The unique structure makes them highly resistant to bacterial beta-lactamase enzymes that can degrade other beta-lactam antibiotics, also allows carbapenems to penetrate the outer membrane of Gram-negative bacteria, making them effective against both Gram-negative and Gram-positive bacteria. Carbapenems are considered as a last resort antibiotic due to their potent activity against a wide range of bacteria, including many that have become resistant to other antibiotics. Since the first carbapenem antibiotic, imipenem, was discovered in 1980s, several other carbapenem antibiotics have been developed, including meropenem, doripenem, ertapenem and biapenem. These antibiotics have played a crucial role in treating serious infections caused by multidrug-resistant bacteria. As a leading provider of research chemicals and biochemicals, we have been instrumental in the development and production of carbapenems for many years. At present, we offer a wide range of carbapenems products.

Our Carbapenem Series Products

Applications of Carbapenems

Carbapenems are a class of broad-spectrum antibiotics that are primarily used to treat serious infections caused by bacteria that are resistant to other types of antibiotics. Some common applications of carbapenems include:

• Treatment of severe infections such as pneumonia, urinary tract infections, sepsis, intra-abdominal infections, bronchopulmonary infection, skin structure infections, gynecologic infections, etc.
• Empirical therapy in hospitalized patients with febrile neutropenia.
• Treatment of infections caused by multidrug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) or extended-spectrum beta-lactamase (ESBL) producing Enterobacteriaceae.
• Prophylactic use in surgical procedures to prevent infections.
• Treatment of healthcare-associated infections, such as ventilator-associated pneumonia or catheter-related bloodstream infections.

It is important to note that carbapenems should be used judiciously to prevent the development of antibiotic resistance and minimize the risk of side effects. They are often reserved for serious infections when other antibiotics have failed or if the bacteria causing the infection are known to be resistant to other antibiotics. Moreover, like all antibiotics, carbapenems can cause side effects such as diarrhea, rash, nausea, vomiting, and more serious effects such as seizures.

Mechanism of Action of Carbapenems

As like other β- Lactam antibiotics, the mechanism of action of carbapenems involves disrupting bacterial cell wall synthesis and causing cell death through inhibition of peptidoglycan cross-linking. Specifically, carbapenems exert their bactericidal effect by binding to penicillin-binding proteins (PBPs) (also known as DD-transpeptidases) in the bacterial cell wall, which are enzymes involved in the cross-linking of peptidoglycan chains. This binding inhibits the transpeptidation reaction that is essential for proper cell wall synthesis, leading to cell lysis and death of the bacteria. On the other hand, the inhibition of transpeptidation and crosslinking causes the buildup of new peptidoglycans. This leads to the activation of autolytic hydrolases, which break down the current peptidoglycan layer without replacing it, ultimately further increasing the bactericidal impact.

It should be noted that our service is only used for research, not for clinical use.