Genotoxicity is defined as the mutagenic potential of a substance, or its ability to cause genetic mutations or chromosomal damage. To avoid potential program failure or delays in clinical trials, accurate in vitro genotoxicology testing is essential for evaluating outcomes. In order to effectively bring your program to market, additional mechanistic insight is often required to understand the mode of action and to appropriately plan in vivo follow-up testing.
Our company offers customers professional genetic toxicology testing services, creating testing plans based on pertinent legal specifications and in vitro responses that have been detected. Allow us to shorten the time it takes for your chemical and pharmaceutical products to reach the market.
Service Overview
Before medications are widely used in people, mutagenic potential of diverse goods is evaluated by genotoxicity studies. Given that DNA-reactive chemicals have the potential to trigger carcinogenic processes, screening methods with built-in mode of action data are becoming more and more beneficial for the biological evaluation of possible dangers to humans.
Our company has been assisting clients in the creation of specialized testing plans and the execution of suitable tests to satisfy the particular needs of their chemicals and medications. Our team consists of experts in the field of genetic toxicology, regulatory consultants, and project managers that can offer sound advice to support the investigations of our customers.
Through supplementary services including formulation and analytical chemistry, pathology, and bioassays, our team collaborates closely with other safety assessment groups to improve study findings and integrity. Additionally, we can support and enhance other studies by evaluating genetic toxicology biomarkers and using in situ hybridization, flow cytometry to determine mechanisms of action and, when needed, apoptosis.
Even though in vitro research is the norm, we occasionally use in vivo genotoxicology studies.
Research Capabilities
Our genetic toxicology testing capabilities include, but are not limited to, the following.
| Gene Mutation | - Bacterial mutation-ames mutagenicity (OECD 471)
- Mammalian mutation assay: mouse lymphoma assay
- HPRT-test
- Pig-a gene mutation assay
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| Chromosome Damage | In Vitro Cytogenics | - Micronucleus assay
- Chromosome aberration test
- 3D skin model combined with micronucleus assay
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| In Vivo Cytogenics | - Micronucleus assay
- Chromosome aberration test
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| DNA Strand Breaking Properties | - Comet assay (in vitro and in vivo)
- Combination of micronucleus and comet assay
- 3D skin model combined with micronucleus assay
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| Additional Tests | - Embryonic stem cell test
- Drug uptake in vitro
- Hepatocyte proliferation assay in vitro (mouse, rat, dog, human)
- Specific assay establishment
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Overall Solutions
| Project Name | Genetic Toxicology Testing Service |
| Service Details | - Genotoxicity assays for genetic toxicology studies
- Screening assays
- In vitro GLP assays
- In vitro follow-up mode of action assessment
- In vitro GLP assay
- Others
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| Deliverables | Within agreed time, we will provide the summary to experiment data and conclusions, as well as a final experiment report. |
| Cycle | Decide according to your needs. |
For more information, please feel free to contact us.
It should be noted that our service is only used for research, not for clinical use.
