Metal Catalysis Technology Platform
Metal Catalysis Technology Platform

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Metal Catalysis Technology Platform

Metal catalysis has emerged as a powerful tool in the field of drug research and development. Firstly, metal catalysis can catalyze a wide range of reactions that are difficult or impossible to achieve using traditional organic catalysts. This allows for the development of novel synthetic routes to drug molecules and the exploration of new chemical space. In addition, they can promote selective transformations, allowing for the synthesis of complex drug molecules with high stereo- and regioselectivity, so as to improve and optimize the function of drugs. However, the metal catalytic reaction system is huge and the content is complicated. The reaction characteristics of different metals involved in metal-catalyzed reactions are very different. Even if the same metal participates in different reactions, the reaction mechanism will be different, which brings trouble to practitioners who want to use the flexibility of metal-catalyzed reactions to synthesize drug molecules.

Our company has developed a cutting-edge metal catalysis technology platform. With our state-of-the-art equipment and expertise in metal catalysis, our platform is dedicated to providing cutting-edge solutions for our clients, including pharmaceutical companies, academic institutions, and research organizations, to support drug discovery and development.

Platform Capacities

  • We have independently synthesized over hundreds of  metal catalysts. These catalysts have been strategically designed to efficiently facilitate various chemical reactions, aiding in the synthesis of novel drug candidates.
  • We have successfully established cooperation with internationally renowned catalyst companies. This collaboration has enabled us to exchange expertise, share resources, and stay updated with the latest advancements in catalyst technology, ensuring that we can offer cutting-edge solutions to meet the diverse needs of our clients in drug R&D.
  • We have a comprehensive inventory of more than 100 commonly used catalysts and ligands with excellent chiral and site selectivity that contribute to the successful development of pharmacologically active compounds with enhanced properties.
  • We have the capabilities to perform a variety of metal-catalyzed reactions, including:
    • Asymmetric hydrogenation
    • Suzuki coupling
    • Carbonylation reaction
    • Ullmann coupling
    • Boronic ester reaction
    • Buchwald-Hartwig coupling
    • Heck reaction
    • Negishi coupling
    • Asymmetric epoxidation
    • Miyaura

Our Metal Catalysis Technology Platform

At our metal catalysis technology platform, we offer a comprehensive service that leverages the power of metal catalysis to support drug discovery and development efforts. Our services include:

  • Metal catalyst development and optimization for various types of drug chemical transformations.
  • Design, selection, development and optimization of metal catalyst ligands.
  • Metal catalyst screening and selection.
  • Metal-catalyzed drug synthesis reactions development and optimization.
  • Metal-catalyzed API and intermediates synthesis.
  • Transferring laboratory-scale metal-catalyzed drug reactions to industrial production processes.
  • Recycle of precious metals catalysts used in the production of chemical synthetic APIs.

Platform Advantages

  • Expertise: Our team of chemists and engineers bring a wealth of experience in metal catalysis and drug discovery. We combine academic knowledge with industry insights to deliver cutting-edge solutions that address complex challenges in pharmaceutical R&D.
  • Customization: We understand that each drug development project is unique, with distinct requirements and constraints. Our service is tailored to accommodate the specific needs of our clients, offering customized solutions that align with project goals and timelines.
  • Quality Assurance: We adhere to the highest standards of quality and safety in our metal catalysis processes. Through rigorous quality control measures and adherence to regulatory guidelines, we ensure that our clients receive reliable and reproducible results.
  • Collaboration: We foster a collaborative partnership with our clients, engaging in open communication and knowledge sharing throughout the project lifecycle. By working closely with our clients, we aim to achieve shared objectives and drive innovation in drug R&D.

It should be noted that our service is only used for research, not for clinical use.

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