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Sustained and Controlled Release Preparation R&D Platform

Sustained and controlled release preparations refer to medication that are designed to release their active ingredients gradually over an extended period of time. This slow release of the medication allows for more consistent blood levels of the drug, reducing the frequency of dosing and potentially minimizing side effects. These preparations can be achieved through various technological approaches, such as coating the drug in a slow-dissolving material, encapsulating them in a biodegradable polymer, or incorporating them into a matrix that releases the drug slowly as they breaks down. Compared to traditional immediate-release preparations, the benefits of sustained and controlled release preparations include improved patient compliance, reduced peak-to-trough fluctuations in drug levels, and potentially enhanced therapeutic efficacy. Sustained and controlled release preparations provide a convenient and effective way to deliver medication to patients in a controlled manner.

On the basis of many years of R&D experience, our company has established a complete sustained and controlled release preparation R&D platform. Our sustained and controlled release preparation R&D platform is at the forefront of developing innovative drug delivery systems that ensure optimal release of active pharmaceutical ingredients over extended periods of time. At present, we have successfully developed dosage forms such as sustained-release pellets, gastric retention tablets, gel matrix tablets, waxy matrix tablets, enteric-coated tablets, and osmotic pump tablets.

Our Sustained and Controlled Release Preparation R&D Platform

Our cutting-edge sustained and controlled release preparation R&D platform allows us to provide a range of services to meet the diverse needs of the pharmaceutical industry. Whether you need help developing new sustained and controlled release preparations or improving the performance of existing sustained and controlled release preparations, our controlled-release preparation R&D platform provides comprehensive services to support your drug development efforts. The services we provide include:

Formulation Development

We can help you develop sustained and controlled release preparations for multiple drugs, including:

Matrix preparations: A sustained release effect is achieved through the dissolution or pore diffusion of the matrix material. This sustained release mechanism helps maintain therapeutic drug concentrations in the body for prolonged periods, leading to more stable and predictable drug effects.

Enteric-coated preparations: By using new pH-dependent polymer resin materials (such as acrylic resins or cellulose ethers), the drug can be positioned and released at the back end of the digestive tract, thereby reducing gastric irritation and targeted drug delivery.

Osmotic pump preparations: Osmotic pump preparations utilize osmotic pressure to control drug release, with osmotic pump tablets being the most frequently used form. Once ingested, gastrointestinal fluid enters the tablet via a semipermeable membrane, causing drug dissolution. By balancing osmotic pressures and the action of propellants, the drug is evenly released through the drug release holes at a constant rate.

Preparation Performance Optimization

Utilizing cutting-edge technologies and methods, we can help you optimize the performance of sustained and controlled release preparations to maximize their efficacy, safety and patient compliance.

In addition, we also provide preclinical research and scale-up production services for sustained and controlled release formulations. Our team of experts can perform in vitro and in vivo studies to evaluate the safety and effectiveness of your sustained and controlled release formulations. And we can help you scale up production of your formulations for clinical trials and commercialization.

Platform Equipment

Our company is equipped with advanced sustained and controlled release formulation equipment and testing instruments, including:

Laser drilling machines
Double-layer tablet presses
Fluidized beds
Melt granulators
Coating machines
Fully automatic sampling dissolution apparatus
Reciprocating cylinder dissolution apparatus
...

It should be noted that our service is only used for research, not for clinical use.

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