In vitro biology offers professional assistance for medication development and discovery. In order to support the in vitro pharmacological characterization of compounds as part of proposition expansion, lead identification, and lead optimization programs, Our company offers customers professional in vitro biology services, producing high-quality data pertinent to the project in a timely manner. We have cutting-edge in vitro pharmacology services facilities, including sophisticated liquid handling, substance handling, and analytical detection technologies, to support these analyses.
Service Overview
Our company offers a multi-level, comprehensive range of services and has specialized knowledge of in vitro biology and cutting-edge screening platforms. The range of services of the company comprises drug target validation, emergent compound discovery, lead compound transition and optimization, preclinical candidate screening, complicated cellular screens, mechanism of action research, and preliminary translational biology studies. Each project includes biomarker research and development, ensuring the co-development of pharmacodynamics, patient stratification, and toxicological biomarkers.
Our team brings together diverse talents with experience in biochemistry, cell biology, high-throughput screening, structural biology, electrophysiology, and protein engineering. Based on the model diagnostic platform, the scientific team is familiar not only with small molecule drug development but also with various biological, gene therapy and cellular therapeutic approaches.
With these advanced technologies and platforms, we can help our clients address a variety of major diseases, including oncology, immune tumors, metabolic diseases, immune and inflammatory disorders, and neurological disorders.
Research Capabilities
In Vitro Screening
Our company is dedicated to taking new compounds from the early stages of development to clinical development. A comprehensive R&D platform and flexible collaboration approach allows for refined services at multiple stages of drug development, involving method development, model building, high-throughput screening, primary screening, cell-level screening, selectivity testing, and in vitro drug safety evaluation.
- Readout and Analytical Techniques
Our extensive biochemical, biophysical and cellular analytical techniques will be combined with many readouts to reveal the true mechanism of action of compounds to aid in the selection, optimization and/or validation of optimal chemical, biological or cellular lead compounds. In addition we offer a variety of cell-based assays and biophysical analysis techniques to support our services.
We perform cell- and tissue-based imaging analyses using advanced imaging equipment. A variety of cellular model systems have been successfully evaluated, including primary neuronal cultures, kidney cells, immune cells, tumor cells, lung cells, muscle and beta cells, and patient-derived stem cells.
To meet the problems of ion channel drug development, our ion channel laboratory brings together skilled electrophysiologists with knowledge of drug discovery, cutting-edge HTS gear, and biophysical characterization of channel function. Many medicinal chemistry projects are supported by the ion channel group, which provides weekly turnaround times and project management.
In Vitro Disease Biology
Our company works closely with partners to design flexible experimental protocols and workflows to achieve specific project goals in the evaluation of drug targets and the development and validation of drug efficacy approaches.
Our company has significant expertise in a wide range of oncology areas, including signal transduction, cancer metabolism, tumor microenvironment, immuno-oncology, tumor metastasis and angiogenesis, DNA damage, and epigenetics. To describe tumor and microenvironment conditions, we incorporate tests based on cells associated with cancer and/or the microenvironment in 2D, co-cultures, or 3D cultures.
We have state-of-the-art microbiology facilities and a full range of in vitro assays to study the following pathogens.
(1) Gram-positive and Gram-negative bacteria including those covering ESKAPE pathogens.
(2) Fungi, including Candida, Aspergillus, etc.
(3) Viruses including respiratory syncytial virus.
(4) Parasites including Toxoplasma gondii.
If you are looking for smarter, higher quality solutions that incorporate best practices, please feel free to contact us.
Related Services
It should be noted that our service is only used for research, not for clinical use.
