Solid state research on small molecule chemical drugs has become a hot topic in pharmaceutical research in recent years during the early development of new drugs and preclinical drug discovery. The vast majority of chemical drugs that have been marketed are administered in solid form, with crystalline forms being the most common. Different solid forms can affect the solubility, bioavailability, stability, hygroscopicity, powder and fluidity of the drug, resulting in different dissolution and absorption rates of the drug in the human body, which in turn affects the dissolution and release of downstream preparations, thereby determining their clinical efficacy and safety. Therefore, solid state research is critical for the discovery, development, and optimization of small molecule drugs.
Our company has developed a cutting-edge solid state research technology platform that focuses on the study and optimization of small molecule drugs. The platform can find the most suitable solid state form for development of candidate drug molecules, and can discover and select advantageous crystal forms or salt forms during the drug development process. In addition, we can solve problems related to drug formulation and manufacturing by optimizing the physical form of drugs, in order to improve their performance and stability. Through our solid state research technology platform, we can accelerate the drug development process, reduce the risk of clinical trial failure, and ultimately bring safer, more effective small molecule drugs to the market.
Our Solid State Research Technology Platform
Through our solid state research technology platform, we offer a range of services aimed at advancing small molecule drug development and optimization. The services we provide mainly include the following aspects.
Polymorph screening: We provide comprehensive polymorph screening services to identify and characterize different solid forms of a small molecule drug. This is crucial for understanding the potential impact of polymorphism on drug stability, solubility, and bioavailability.
Salt screening: We provide salt screening services to explore different salt forms of a drug molecule. Salt selection can significantly impact a drug's physicochemical properties and ultimately its efficacy in vivo.
Co-crystal screening: We offer co-crystal screening services to investigate the potential for forming co-crystals of a drug molecule with other compounds. Co-crystals can enhance drug stability, solubility, and bioavailability.
Solid-state characterization: We provide solid-state characterization services for drug molecules. The crystalline structure and properties of drug molecules are analyzed using techniques such as powder X-ray diffraction, thermal analysis, and solid-state nuclear magnetic resonance (NMR).
Drug analysis and testing: Analysis and testing items include pKa, Log P, Log D, crystal form analysis, thermal analysis, powder properties, particle size, qualitative and quantitative development and verification of crystal forms in raw materials or preparations, etc.
Crystallization process development: Crystallization process development can be carried out for APIs and intermediates with crystal forms and particle size requirements, which is beneficial to material separation operations in the workshop and improves purity.
Formulation development: We assist in developing optimized drug formulations by leveraging our understanding of solid-state properties to improve drug stability, solubility, and manufacturability.
Platform Equipment
Solid state research technology platforms typically utilize a range of specialized equipment to study the physical properties of small molecule drugs in solid form. Some common equipment includes:
- Ion chromatograph
- Laser particle size analyzer
- Polarizing microscope
- Thermogravimetric analyzer (TGA)
- X-ray diffractometer
- Differential scanning calorimeter (DSC)
- High-performance liquid chromatograph
- Online particle size and shape measuring instrument
Related Services
It should be noted that our service is only used for research, not for clinical use.
