In Vitro Toxicity Testing Service

In vitro toxicity tests are used to determine the potential for new drugs, agrochemicals, food additives, or other chemical products to be harmful to humans. To prevent the needless use of animals in selecting which medication candidates should be pursued for additional safety testing, in vitro investigations on grown bacteria or mammalian cells can be employed as an initial screening method.

Our company provides in vitro toxicology testing services, as well as in chemical and in silico testing techniques, as an alternative to conventional animal toxicity testing. We offer qualitative and quantitative data through our in vitro toxicology testing services to support metabolic, toxicokinetic, and bioanalytical studies.

Service Overview

A crucial technique for minimizing attrition in the discovery and development of innovative drug candidates is in vitro toxicity screening approaches. Our company provides a broad range of services along the in vitro toxicity assay continuum, as well as a complete array of in vitro toxicology assays. We have been at the vanguard of creating, validating, and accepting a range of animal-free models, and many of our assays serve as direct equivalents to testing or screening on animals.

In vitro human, animal, and 3D tissue substitutes have effectively replaced many acute toxicity tests. Models of skin irritability, skin corrosion, and skin sensitization - all of which are amply supported here - show this transition most clearly. Additionally, there are models for evaluating serious harm, eye irritation, and phototoxicity. Additionally, we are creating models to evaluate toxicity and effectiveness in additional tissues, including the intestine, oral cavity, and lung.

Research Capabilities

Our company offers a wide range of in vitro toxicology testing methods for the toxicological risk assessment of our customers' products. Our comprehensive analytical capabilities for in vitro toxicity testing include:

Dermal Toxicity

Epidermal testing can be used alone or in combination to differentiate between non-irritants/non-corrosives and irritants/corrosives.

• In vitro skin irritation test (reconstructed human epidermal (RhE) model)
• In vitro skin corrosion test (reconstructed human epidermis (RhE) model)

Qualitative and Quantitative Cytotoxicity

Qualitative cytotoxicity testing uses a numerical grading system to determine the toxicity of medical devices and their extracts to cells.

For our bioreactivity testing:

• Direct contact
• Agar diffusion
• Elution

Genotoxicity

Genotoxicity testing determines the potential for products to cause genetic mutations and chromosomal damage. Tests are performed using bacterial and mammalian systems.

• Ames (bacterial genetic mutations)
• Micronucleus test (chromosome damage in mammalian cells)

Eye irritation

The eye irritation test assesses whether the substance causes reversible or irreversible damage to the eye.

• In vitro eye irritation test (reconstructed human corneal-like epidermis)

Phototoxicity

Phototoxicity tests predict whether a toxic reaction is likely to be caused by dermal exposure or systemic administration of a substance followed by exposure to light.

• Phototoxicity test (cell viability test)

Permeability

Permeability tests predict the intestinal absorption and bioavailability of a drug and are used to determine the permeability class of a drug or substance.

• In vitro permeability test: Caco-2 cell monolayer permeability test

Overall Solutions

For more information, please feel free to contact us.

It should be noted that our service is only used for research, not for clinical use.