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DNA-Encoded Library (DEL) Services

DNA-Encoded Library (DEL) is a powerful technology used in pharmaceutical research to assist in the discovery of new drugs. The technique involves synthesizing large collections of small molecule compounds, each attached to a unique piece of DNA, which serves as a "bar code" for the molecule. This allows for the rapid and high-throughput screening and identification of compounds that bind to a target protein by using DNA sequencing techniques to read the barcode associated with the compound ^[1]. Therefore, DELs have become an important tool in drug discovery, as they enable the screening of millions of compounds in a single experiment, significantly reducing the time and cost of preclinical drug discovery. Our expert team has extensive experience and deep understanding of the chemical space and the key DEL technology, and we can offer an exceptional suite of services related to DEL technology. At present, our company has accumulated extensive experience by serving many pharmaceutical and biotechnology companies and academic institutions.

Fig. 1. Illustration of the DEL for drug discovery research.

Our Services

comprehensive DNA-Encoded Library (DEL) service

We provide a comprehensive DNA-Encoded Library (DEL) service for drug discovery research. Our service is based on the combination of huge chemical space and high-throughput sequencing technology, which aims to significantly enhance the efficiency and cost-effectiveness of drug discovery process. Our DEL service includes the following key project components:

DEL Design: Our expert team can design custom DNA-encoded libraries based on customer requirements and drug discovery targets. Through years of experience, our company has explored and summarized a unique and efficient DEL design idea, which can effectively select the appropriate chemical building blocks and process the encoded DNA sequence scheme.

DEL Screening: We perform high-throughput screening of the synthesized DEL in the presence of a target protein. The target-binding molecules are then enriched and identified through DNA sequencing. Our DEL screening can serve hit identification, hit optimization, protein degradation molecule discovery/optimization, etc.

DEL Synthesis: We synthesize the designed libraries using advanced DNA-tagging techniques. During the process, each chemical building block is attached with a unique coding DNA, forming a large diversity of small molecule-DNA conjugates. We develop vast DNA-compatible chemical reactions, and have tens of thousands of building blocks as well as automated platforms that support the whole process of library synthesis, which can accurately and efficiently parallel tens of thousands of reactions. This allows us to complete product delivery quickly. At the same time, we have established a sound process control and final product quality evaluation system to ensure quality.

Data Analysis: Lastly, we offer comprehensive data analysis support to interpret the screening results, providing insights on binding affinities, structure-activity relationships, specificity, etc.

Why Choose Us?

Rich Experience

Our team of scientists and experts have years of experience in the field of drug discovery and genomic research, enabling us to provide high-quality, customizable and efficient DEL services.

Customizable Solutions

We understand that every project is unique. We offer customizable solutions suitable for big pharma, biotech, academia and research institutes to meet the specific needs of our clients.

Unparalleled Support

We offer comprehensive consultation and support to our clients throughout the process. Our aim is to ensure you achieve your research objectives with ease and speed.

Quality Assurance

We strictly adhere to quality control standards and all our processes comply with regulatory requirements. This ensures the results you receive are reliable and replicable for your research.

Timely Delivery

We are committed to completing projects on time, without compromising the quality of our services.

Reference

Gironda-Martínez A., et al. DNA-encoded chemical libraries: a comprehensive review with successful stories and future challenges[J]. ACS Pharmacology & Translational Science, 2021, 4(4): 1265-1279.

It should be noted that our service is only used for research, not for clinical use.

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