Other Disease Pharmacodynamic Research

Pharmacodynamic research is the assessment of a drug's efficacy with the goal of clarifying the mechanisms of illness diagnosis and prevention, as well as providing a scientific foundation for the creation and assessment of pharmaceuticals. Our company has extensive experience in pharmacodynamic (PD) studies and can complete PD studies on a wide range of diseases, including metabolic diseases, anti-inflammatory immune, respiratory, and urological diseases, in addition to its main studies on oncology, cardiovascular diseases, and neurodegenerative diseases.

Metabolic Diseases

We can provide primary and functional cell culture services, including adipocytes, islet cells, etc. We can also help our clients construct a series of metabolic disease models, such as diabetes, hyperlipidemia, and hyperuricemia. Based on these models, we can conduct research on the pathogenesis of related diseases and evaluate the efficacy of drugs.

Inflammatory Immune Diseases

Respiratory Diseases

Pulmonary Fibrosis

• Animal: C57BL/6 mice.
• Experimental method: The lung fibrosis model was induced by tracheal injection using 2.5 mg/kg bleomycin.
• Test index: HE staining, Masson, lung index W/D measurement.

Urinary Tract Diseases

We can provide pathogenic microbial culture services, including group B Streptococcus, Candida albicans, and Escherichia coli. We can also help our customers construct drug and surgery-induced kidney injury disease models.

• Animals: SD rats, ICR mice.
• Methods: Chemotherapeutic drugs (Adriamycin), renal ischemia-reperfusion.
• Test index: Renal function, urine protein, creatinine clearance, etc.

Liver Diseases

Our company can construct liver fibrosis models and provide related efficacy evaluation services.

• Animals: ICR mice, SD rats.
• Methods: CCl4 intraperitoneal injection, bovine serum albumin intraperitoneal injection, common bile duct ligation.
• Test index: Liver function (ALT, AST, TBIL), liver fibrosis quadruple (HA, LN, CIV, PIIIPN), histopathology of liver disease (HE staining and collagen fiber staining).

If you are looking for the best solution in the field of PD studies of drugs for human use, please feel free to contact us.

Reference

1. Ji E, et al. (2021). "Antibody-Based Therapeutics for Atherosclerosis and Cardiovascular Diseases." Jnt. J. Mol. Sci. 22(11): 5770.

It should be noted that our service is only used for research, not for clinical use.