Pharmacodynamic research is the assessment of a drug's efficacy with the goal of clarifying the mechanisms of illness diagnosis and prevention, as well as providing a scientific foundation for the creation and assessment of pharmaceuticals. Our company has extensive experience in pharmacodynamic (PD) studies and can complete PD studies on a wide range of diseases, including metabolic diseases, anti-inflammatory immune, respiratory, and urological diseases, in addition to its main studies on oncology, cardiovascular diseases, and neurodegenerative diseases.
Metabolic Diseases
We can provide primary and functional cell culture services, including adipocytes, islet cells, etc. We can also help our clients construct a series of metabolic disease models, such as diabetes, hyperlipidemia, and hyperuricemia. Based on these models, we can conduct research on the pathogenesis of related diseases and evaluate the efficacy of drugs.
| Animals | Modeling methods | Detection indexes |
| Diabetes Mellitus | db/db mice (type II), ob/ob mice (type II), NOD mice (type I), GK rats. | High-fat diet feeding method. | Blood biochemical index. |
| Hyperlipidemia | 1CR mice, SD rats, New Zealand free, rhesus monkeys. | High-fat diet feeding method. | Serum TG, CHO, LDL, HDL, VLDL, liver TG and CHO, Apolipoprotein A/B. |
| Hyperuricemia | ICR mice, SD rats. | High adenine, high-fat feed. | Uric acid, renal function and serum electrolytes, joint histopathology. |
| Metabolic acidosis | New Zealand free, Beagle dogs. | Intravenous injection. | Serum electrolytes and acid-base analysis, blood pressure and blood glucose. |
Inflammatory Immune Diseases
| Animals | Modeling methods | Detection indexes |
| Enteritis | Mice/Rats. | Whole colonic perfusion with anal trinitrobenzene sulfonic acid sodium (TNBS). | Gross inflammation level score, pathological hematoxylin-eosin (HE) staining enteritis index. |
| cGVHD Scleroderma | Donor C57BL/6 mice, recipient B6D2F1 mice. | Bone marrow cells from donor C57BL/6 mice were transplanted into X-Ray irradiated recipient B6D2F1 mice. | Clinical symptoms score of transplanted animals, skin and lung pathology score of the model. |
| Renal Fibrosis | Mouse. | Unilateral ureteral obstruction. | Renal ultrasonography, renal pathology HE staining, PCR and Western blot for connective tissue growth factor (CTGF). |
Respiratory Diseases
Pulmonary Fibrosis
- Animal: C57BL/6 mice.
- Experimental method: The lung fibrosis model was induced by tracheal injection using 2.5 mg/kg bleomycin.
- Test index: HE staining, Masson, lung index W/D measurement.
Urinary Tract Diseases
We can provide pathogenic microbial culture services, including group B Streptococcus, Candida albicans, and Escherichia coli. We can also help our customers construct drug and surgery-induced kidney injury disease models.
- Animals: SD rats, ICR mice.
- Methods: Chemotherapeutic drugs (Adriamycin), renal ischemia-reperfusion.
- Test index: Renal function, urine protein, creatinine clearance, etc.
Liver Diseases
Our company can construct liver fibrosis models and provide related efficacy evaluation services.
- Animals: ICR mice, SD rats.
- Methods: CCl4 intraperitoneal injection, bovine serum albumin intraperitoneal injection, common bile duct ligation.
- Test index: Liver function (ALT, AST, TBIL), liver fibrosis quadruple (HA, LN, CIV, PIIIPN), histopathology of liver disease (HE staining and collagen fiber staining).
If you are looking for the best solution in the field of PD studies of drugs for human use, please feel free to contact us.
Reference
- Ji E, et al. (2021). "Antibody-Based Therapeutics for Atherosclerosis and Cardiovascular Diseases." Jnt. J. Mol. Sci. 22(11): 5770.
It should be noted that our service is only used for research, not for clinical use.
