Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, and others are examples of neurodegenerative diseases, which are a group of irreversible impairment diseases in which the body's loss of neuronal structure or function causes cognitive and motor impairment. The complex pathogenesis of these diseases and the lack of effective therapeutic agents have become a focus of research in both basic and clinical science.
Our company offers pharmacodynamic (PD) solutions for the study of neurodegenerative diseases to aid in the development of therapeutics for these diseases. We have listed our specific solutions below.
In Vitro Neuronal Cell Research
We can provide primary neuronal cell culture services, including hippocampal primary cardiac primary cells, vascular endothelial cells, and brain hippocampal neuronal cells.
Research and testing tools
- Flow cytometry for cell function (death, regulation, autophagy, etc.) and cellular molecular markers.
- Western blot and polymerase chain reaction (PCR) for protein and gene expression assays, respectively.
In Vivo PD Studies
We combine a variety of animal models of disease and can provide neurological functional assays and behavioral analysis.
| Animals | Modeling methods | Detection indexes |
| Dementia Models | Transgenic mice, SAMP8 aged mice, rats, non-human primates. | D-galactose, lateral ventricular injection of AB1-40, common carotid artery ligation, sleep disturbance. | Behavioral indexes Morris water maze, new object recognition, shuttle, jumping platform. Brain group pathology, hippocampal neuro synaptic abnormalities index. |
| Parkinson's Model | C57 mice, SD rats. | MPTP modeling, lateral ventricle injection of monoamine oxidase. | Autonomic activity, rotation test, striatal DA and monoamine oxidase, etc. |
| Epilepsy Model | C57 mice, SD rats. | Li-Pilocarpine chloride, pentetracycline (PTZ). | Seizure rating, neuronal damage in the brain, hippocampal glial cells, neurotransmitters (glutamate, GABA, glycine, Ach), etc. |
| Depression Model | ICR mice, C57 mice, SD rats, and WKY rats. | Chronic restraint stress, olfactory bulb removal, chronic unpredictable stimulation, reserpine antagonism, social frustration. | Feeding inhibition, sugar-water preference, tail suspension, forced swimming. |
| Fear Model | ICR mice, SD rats. | Electroshock method | Rigidity |
Behavioral Analysis Studies
- Learning and memory ability of mice: An open field experiment, new object recognition experiment, Y-maze experiment, water-maze experiment.
- Mice motor ability detection: Grasping force experiment, fatigue rotating bar experiment, treadmill experiment, pole climbing experiment.
- Mice depression detection: Sugar-water preference experiment, open-field experiment, hanging tail experiment, forced swimming experiment.
- Anxiety detection in mice: Open field activity experiment, elevated cross experiment.
If you are looking for the best solution in the field of PD studies of drugs for human use, please feel free to contact us.
Related Solutions
It should be noted that our service is only used for research, not for clinical use.
