Nicotinamide

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Nicotinamide

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Catalog Number	PR98920
CAS	98-92-0
Structure
Description	An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and pellagra. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
Synonyms	3-Pyridinecarboxamide
IUPAC Name	pyridine-3-carboxamide
Molecular Weight	122.12
Molecular Formula	C6H6N2O
InChI	DFPAKSUCGFBDDF-UHFFFAOYSA-N
InChI Key	InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
Associated Therapies	Dietary and Nutritional Therapies, Nutritional supplementation, Dietary supplementation
Drug Categories	Alimentary Tract and Metabolism; Cytochrome P-450 CYP2D6 Inhibitors; Cytochrome P-450 CYP2D6 Inhibitors (strength unknown); Cytochrome P-450 CYP2E1 Inhibitors; Cytochrome P-450 CYP2E1 Inhibitors (strength unknown); Cytochrome P-450 CYP2E1 Substrates; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 CYP3A4 Inhibitors; Cytochrome P-450 CYP3A4 Inhibitors (strength unknown); Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Substrates; Micronutrients; Nicotinic Acids; Pyridines; Vitamin B Complex; Vitamins
Isomeric SMILES	C1=CC(=CN=C1)C(=O)N
Type	Small Molecule
Therapeutic Category	Supplyments

Pharmacology

Mechanism of Action

Nicotinamide is known to influence various biological processes through its interaction with multiple enzymes and pathways. It acts on ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase, which is significant in human cellular mechanisms. Additionally, nicotinamide has a binding relationship with Poly [ADP-ribose] polymerase 1, another critical enzyme in human biological functions. While the complete spectrum of its role in NAD-dependent protein deacylase sirtuin-5 and L-lactate dehydrogenase A chain in humans is still under investigation, its interaction with exotoxin A, a product of Pseudomonas aeruginosa, further exemplifies its diverse mechanism of action.

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