Fmoc-His-Aib-OH TFA

Fmoc-His-Aib-OH TFA

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Fmoc-His-Aib-OH TFA

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Fmoc-His-Aib-OH TFA

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Catalog Number	PR1446013086
CAS	1446013-08-6
Structure
Description	Used as a starting material for the synthesis of semaglutide, this product inserts histidine and modified amino acids (alanine → α-aminoisobutyric acid, resistant to DPP-4 degradation) at the 7th and 8th positions of semaglutide, respectively.
Synonyms	(S)-2-(2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(1H-imidazol-5-yl)propanamido)-2-methylpropanoic acid 2,2,2-trifluoroacetate
IUPAC Name	2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-(1H-imidazol-5-yl)propanoyl]amino]-2-methylpropanoic acid;2,2,2-trifluoroacetic acid
Molecular Weight	576.53
Molecular Formula	C27H27F3N4O7
InChI	InChI=1S/C25H26N4O5.C2HF3O2/c1-25(2,23(31)32)29-22(30)21(11-15-12-26-14-27-15)28-24(33)34-13-20-18-9-5-3-7-16(18)17-8-4-6-10-19(17)20;3-2(4,5)1(6)7/h3-10,12,14,20-21H,11,13H2,1-2H3,(H,26,27)(H,28,33)(H,29,30)(H,31,32);(H,6,7)/t21-;/m0./s1
InChI Key	HKIYFCVPNDIRNF-BOXHHOBZSA-N
Purity	≥99%
Appearance	White or off-white solid
Applications/Corresponding APIs	Semaglutide
EC Number	815-122-7
Isomeric SMILES	CC(C)(C(=O)O)NC(=O)[C@H](CC1=CN=CN1)NC(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24.C(=O)(C(F)(F)F)O
Storage Conditions	Sealed, refrigerated (2-8 °C)

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