Elinzanetant

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Elinzanetant

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Catalog Number	PR929046333
CAS	929046-33-3
Description	Elinzanetant is an orally bioavailable neurokinin/tachykinin 1 receptor (NK1-receptor; NK1R; NK-1R) and NK3 receptor (NK-3R; NK3R) antagonist, that may be used to treat vasomotor symptoms in menopausal woman.
IUPAC Name	N-[6-[(7S,9aS)-7-(hydroxymethyl)-3,4,6,7,9,9a-hexahydro-1H-pyrazino[2,1-c][1,4]oxazin-8-yl]-4-(4-fluoro-2-methylphenyl)pyridin-3-yl]-2-[3,5-bis(trifluoromethyl)phenyl]-N,2-dimethylpropanamide
Molecular Weight	668.6
Molecular Formula	C33H35F7N4O3
InChI	DWRIJNIPBUFCQS-DQEYMECFSA-N
InChI Key	InChI=1S/C33H35F7N4O3/c1-19-9-23(34)5-6-26(19)27-13-29(44-16-25-18-47-8-7-43(25)15-24(44)17-45)41-14-28(27)42(4)30(46)31(2,3)20-10-21(32(35,36)37)12-22(11-20)33(38,39)40/h5-6,9-14,24-25,45H,7-8,15-18H2,1-4H3/t24-,25-/m0/s1
Isomeric SMILES	CC1=C(C=CC(=C1)F)C2=CC(=NC=C2N(C)C(=O)C(C)(C)C3=CC(=CC(=C3)C(F)(F)F)C(F)(F)F)N4C[C@H]5COCCN5C[C@H]4CO
Type	Small Molecule

Pharmacology

Mechanism of Action

Elinzanetant operates through a dual mechanism of action as both a neuromedin-K receptor antagonist and a substance-P receptor antagonist in humans. By targeting these specific receptors, Elinzanetant effectively modulates the body's response mechanisms that are associated with various physiological processes. The inhibition of the neuromedin-K and substance-P receptors plays a crucial role in the therapeutic effects observed with this product, demonstrating its potential efficacy in addressing conditions linked to these receptor pathways.

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