Ponatinib Hydrochloride

Ponatinib Hydrochloride

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Ponatinib Hydrochloride

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Ponatinib Hydrochloride

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Catalog Number	PR1114544318
CAS	1114544-31-8
Structure
Description	Ponatinib hydrochloride is the hydrochloride salt of ponatinib. It is a potent pan inhibitor of tyrosine kinases, active in all single resistance ABL kinase mutations including the T315l mutation. It is approved for the treatment of chronic myeloid leukemia. It has a role as an antineoplastic agent and a tyrosine kinase inhibitor.
Synonyms	Ponatinib HCl
IUPAC Name	3-(2-imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamide;hydrochloride
Molecular Weight	569.0
Molecular Formula	C29H28ClF3N6O
InChI	InChI=1S/C29H27F3N6O.ClH/c1-20-5-6-22(16-21(20)8-10-25-18-33-27-4-3-11-34-38(25)27)28(39)35-24-9-7-23(26(17-24)29(30,31)32)19-37-14-12-36(2)13-15-37;/h3-7,9,11,16-18H,12-15,19H2,1-2H3,(H,35,39);1H
InChI Key	BWTNNZPNKQIADY-UHFFFAOYSA-N
Applicable Dosage Form	Tablet
EC Number	696-530-0
Isomeric SMILES	CC1=C(C=C(C=C1)C(=O)NC2=CC(=C(C=C2)CN3CCN(CC3)C)C(F)(F)F)C#CC4=CN=C5N4N=CC=C5.Cl
Therapeutic Category	Oncology

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