OPB-171775

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OPB-171775

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Catalog Number	PR2131210154
CAS	2131210-15-4
Description	OPB-171775 is a molecular glue, which forms ternary complex with phosphodiesterase 3A (PDE3A) and schlafen family member 12 (SLFN12). OPB-171775 causes SLFN12 RNase-mediated cell death, activates SLFN12 RNase-associated GCN2 signaling pathway, and exhibits antitumor efficacy.
IUPAC Name	(4R)-3-[2,3-difluoro-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methyl-4,5-dihydro-1H-pyridazin-6-one
Molecular Weight	312.31
Molecular Formula	C15H18F2N2O3
Canonical SMILES	FC1=C(C([C@H](C)C2)=NNC2=O)C=CC(OCC(O)(C)C)=C1F
InChI	InChI=1S/C15H18F2N2O3/c1-8-6-11(20)18-19-14(8)9-4-5-10(13(17)12(9)16)22-7-15(2,3)21/h4-5,8,21H,6-7H2,1-3H3,(H,18,20)/t8-/m1/s1
InChI Key	GGUTYKLJESECBW-MRVPVSSYSA-N
Purity	>99.5%
Appearance	White to off-white solid
Shipping	Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions	Store at 4 °C, protect from light

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