NST-628

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NST-628

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Catalog Number	PR3002056303
CAS	3002056-30-3
Structure
Description	NST-628 is a brain-permeable MAPK pathway molecule glue that inhibits RAF phosphorylation and MEK activation. NST-628 also binds RAF and prevents the formation of BRAF-CRAF and BRAF-ARAF heterodimers, effectively inhibiting the RAS-MAPK pathway.
Synonyms	A1AHE
IUPAC Name	3-[[3-fluoro-2-(methylsulfamoylamino)pyridin-4-yl]methyl]-7-(3-fluoropyridin-2-yl)oxy-4-methylchromen-2-one
Molecular Weight	488.46
Molecular Formula	C22H18F2N4O5S
Canonical SMILES	FC1=C(OC2=CC=C(C(C)=C(CC3=C(F)C(NS(NC)(=O)=O)=NC=C3)C(O4)=O)C4=C2)N=CC=C1
InChI	InChI=1S/C22H18F2N4O5S/c1-12-15-6-5-14(32-21-17(23)4-3-8-27-21)11-18(15)33-22(29)16(12)10-13-7-9-26-20(19(13)24)28-34(30,31)25-2/h3-9,11,25H,10H2,1-2H3,(H,26,28)
InChI Key	YQSZJOABXRROQR-UHFFFAOYSA-N
Purity	>98.5%
Appearance	White to off-white solid
Shipping	Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions	Store at -20 °C

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