LC3-mHTT-IN-AN2

LC3-mHTT-IN-AN2

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LC3-mHTT-IN-AN2

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Catalog Number	PR7758738
CAS	7758-73-8
Description	Compound AN2 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT). AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons.
Synonyms	5,7-dihydroxy-4-phenylcoumarin
IUPAC Name	5,7-dihydroxy-4-phenylchromen-2-one
Molecular Weight	254.24
Molecular Formula	C15H10O4
Canonical SMILES	OC1=CC(O)=C2C(OC(=O)C=C2C2=CC=CC=C2)=C1
InChI	InChI=1S/C15H10O4/c16-10-6-12(17)15-11(9-4-2-1-3-5-9)8-14(18)19-13(15)7-10/h1-8,16-17H
InChI Key	HUQKUJNSVHEHIH-UHFFFAOYSA-N
Purity	≥95%
Solubility	DMSO, DMF
Appearance	White solid
EC Number	622-107-7
Shipping	Room temperature
Storage Conditions	Refrigerated

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