Lanifibranor

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Lanifibranor

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Catalog Number	PR927961180
CAS	927961-18-0
Synonyms	1H-Indole-2-butanoic acid, 1-(6-benzothiazolylsulfonyl)-5-chloro-
IUPAC Name	4-[1-(1,3-benzothiazol-6-ylsulfonyl)-5-chloroindol-2-yl]butanoic acid
Molecular Weight	434.9
Molecular Formula	C19H15ClN2O4S2
InChI	OQDQIFQRNZIEEJ-UHFFFAOYSA-N
InChI Key	InChI=1S/C19H15ClN2O4S2/c20-13-4-7-17-12(8-13)9-14(2-1-3-19(23)24)22(17)28(25,26)15-5-6-16-18(10-15)27-11-21-16/h4-11H,1-3H2,(H,23,24)
Drug Categories	Amides; Heterocyclic Compounds, Fused-Ring; Sulfones; Sulfur Compounds; Thiazoles
Isomeric SMILES	C1=CC2=C(C=C1S(=O)(=O)N3C4=C(C=C(C=C4)Cl)C=C3CCCC(=O)O)SC=N2
Type	Small Molecule
Therapeutic Category	Non-Alcoholic Steatohepatitis (NASH)

Pharmacology

Mechanism of Action

Lanifibranor functions through a multi-faceted mechanism by acting as an agonist for all three isoforms of peroxisome proliferator-activated receptors (PPARs) in humans: PPAR-alpha, PPAR-delta, and PPAR-gamma. This unique activation profile allows Lanifibranor to regulate lipid metabolism, enhance insulin sensitivity, and modulate inflammation. By simultaneously targeting these receptor subtypes, it potentially offers comprehensive therapeutic benefits in treating metabolic diseases by addressing various underlying pathophysiological mechanisms.

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