Ibudilast

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Ibudilast

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Catalog Number	PR50847115
CAS	50847-11-5
Description	Ibudilast is an anti-inflammatory and neuroprotective oral agent.
Synonyms	Ketas; KC-404; MN-166; Ibudilastum
IUPAC Name	2-methyl-1-(2-propan-2-ylpyrazolo[1,5-a]pyridin-3-yl)propan-1-one
Molecular Weight	230.31
Molecular Formula	C14H18N2O
InChI	ZJVFLBOZORBYFE-UHFFFAOYSA-N
InChI Key	InChI=1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3
Drug Categories	Anti-Asthmatic Agents; Antiplatelet agents; Autonomic Agents; Bronchodilator Agents; Cardiovascular Agents; Drugs for Obstructive Airway Diseases; Enzyme Inhibitors; Hematologic Agents; Heterocyclic Compounds, Fused-Ring; Leukotriene Antagonists; Peripheral Nervous System Agents; Phosphodiesterase 5 Inhibitors; Phosphodiesterase Inhibitors; Respiratory System Agents; Vasodilating Agents
Drug Interactions	Abaloparatide-The risk or severity of hypotension can be increased when Ibudilast is combined with Abaloparatide. Abciximab-The risk or severity of bleeding can be increased when Ibudilast is combined with Abciximab. Abrocitinib-The risk or severity of bleeding and thrombocytopenia can be increased when Ibudilast is combined with Abrocitinib. Acebutolol-Ibudilast may increase the antihypertensive activities of Acebutolol. Aceclofenac-The risk or severity of bleeding can be increased when Aceclofenac is combined with Ibudilast.
Half-Life	19 hours
Isomeric SMILES	CC(C)C1=NN2C=CC=CC2=C1C(=O)C(C)C
Standard	In-house
Type	Small Molecule
Therapeutic Category	Ophthalmic Agents

Pharmacology

Mechanism of Action

Ibudilast functions through a multifaceted mechanism of action, incorporating anti-inflammatory and neuroprotective properties. Its anti-inflammatory effects are primarily mediated by the inhibition of phosphodiesterase, which plays a crucial role in modulating inflammatory pathways. Additionally, Ibudilast exhibits neuroprotective capabilities by inhibiting nitric oxide synthesis and reducing the production of reactive oxygen species, thereby contributing to the preservation of neuronal health and function.

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