GW5074

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GW5074

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Catalog Number	PR220904836
CAS	220904-83-6
Structure
Description	GW5074 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT). It is also a potent and selective c-Raf inhibitor with IC50 of 9 nM.
Synonyms	5-Iodo-3-[(3,5-dibromo-4-hydroxyphenyl)methylene]-2-indolinone
IUPAC Name	(3Z)-3-[(3,5-dibromo-4-hydroxyphenyl)methylidene]-5-iodo-1H-indol-2-one
Molecular Weight	520.95
Molecular Formula	C15H8Br2INO2
Canonical SMILES	OC1=C(Br)C=C(\C=C2/C(=O)NC3=C2C=C(I)C=C3)C=C1Br
InChI	InChI=1S/C15H8Br2INO2/c16-11-4-7(5-12(17)14(11)20)3-10-9-6-8(18)1-2-13(9)19-15(10)21/h1-6,20H,(H,19,21)/b10-3-
InChI Key	LMXYVLFTZRPNRV-KMKOMSMNSA-N
Purity	≥95%
Solubility	DMSO, DMF
Appearance	White solid
Shipping	Room temperature
Storage Conditions	Refrigerated

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