Edetate Disodium

Indications

Edetate Disodium is primarily indicated for the emergency management of hypercalcemia, as well as ventricular arrhythmias associated with digitalis toxicity. Its use is critical in situations where rapid reduction of blood calcium levels or mitigation of digitalis toxicity is required to stabilize the patient.

Pharmacodynamics

Functioning as a polyvalent ion chelator, Edetate Disodium effectively reduces the concentrations of calcium and digitalis in the bloodstream. It exhibits a prolonged duration of action, enabling it to be administered once daily. The therapeutic index of this chelator is notably broad, with high doses generally being well-tolerated. Nonetheless, patients should be advised about potential side effects, including postural hypotension, impacts on myocardial contractility, and the risk of hypokalemia, hypomagnesemia, and hypoglycemia.

Metabolism

Edetate Disodium is processed in the body with minimal metabolic transformation, remaining largely unmetabolized.

Mechanism of Action

Edetate Disodium functions by chelating divalent and trivalent metal ions, including magnesium, zinc, and calcium. This chelation process facilitates the excretion of these ions through the urine, thereby reducing their concentrations in the bloodstream.