Dexibuprofen

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Dexibuprofen

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Catalog Number	PR51146566
CAS	51146-56-6
Structure
Description	Dexibuprofen is an ibuprofen. It has a role as a non-narcotic analgesic and a non-steroidal anti-inflammatory drug. It is an enantiomer of a levibuprofen.
Synonyms	(S)-Ibuprofen
IUPAC Name	(2S)-2-[4-(2-methylpropyl)phenyl]propanoic acid
Molecular Weight	206.28
Molecular Formula	C13H18O2
InChI	HEFNNWSXXWATRW-JTQLQIEISA-N
InChI Key	InChI=1S/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/t10-/m0/s1
Associated Therapies	Analgesia
Documentation/Certification	GMP / DMF
Drug Categories	Acids, Carbocyclic; Agents causing hyperkalemia; Agents that produce hypertension; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Anti-Inflammatory Agents, Non-Steroidal (Non-Selective); Antiinflammatory and Antirheumatic Products; Antiinflammatory and Antirheumatic Products, Non-Steroids; Cytochrome P-450 CYP2C19 Substrates; Cytochrome P-450 CYP2C8 Substrates; Cytochrome P-450 CYP2C9 Substrates; Cytochrome P-450 Substrates; Musculo-Skeletal System; Nephrotoxic agents; Non COX-2 selective NSAIDS; Phenylpropionates; Propionates; UGT1A1 Substrates; UGT1A3 substrates; UGT1A9 Substrates; UGT2B7 substrates
Drug Interactions	Abacavir-Dexibuprofen may decrease the excretion rate of Abacavir which could result in a higher serum level. Abatacept-The metabolism of Dexibuprofen can be increased when combined with Abatacept. Abciximab-The risk or severity of bleeding can be increased when Dexibuprofen is combined with Abciximab. Abiraterone-The metabolism of Dexibuprofen can be decreased when combined with Abiraterone. Abrocitinib-The metabolism of Abrocitinib can be decreased when combined with Dexibuprofen.
Isomeric SMILES	C[C@@H](C1=CC=C(C=C1)CC(C)C)C(=O)O
Type	Small Molecule
Therapeutic Category	Anti-Inflammatory Agents

Pharmacology

Mechanism of Action

Dexibuprofen, similar to other nonsteroidal anti-inflammatory drugs (NSAIDs), functions as the active enantiomer of ibuprofen. It operates by inhibiting the COX-2 isoform of the arachidonic acid cycle, effectively reducing the production of prostanoids in inflammatory cells. This targeted inhibition helps manage inflammation and pain, aligning with the mechanisms attributed to ibuprofen.

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