Indications
Deslanoside is primarily indicated for the treatment and management of cardiac conditions such as congestive heart failure, certain types of arrhythmias, and heart failure. It is particularly beneficial for patients experiencing supraventricular arrhythmias due to reentry mechanisms and is also used to control ventricular rates in chronic atrial fibrillation cases.
Pharmacodynamics
Deslanoside functions as a cardiac glycoside and plays a crucial role in enhancing cardiac efficiency. It aids in improving the strength and efficiency of heart contractions, thereby improving cardiac output and alleviating symptoms associated with heart failure. Additionally, Deslanoside is effective in the management of supraventricular arrhythmias, helping to regulate abnormal heart rhythms and providing rate control in conditions such as chronic atrial fibrillation.
Absorption
When administered, Deslanoside exhibits limited absorption from the gastrointestinal tract, with an absorption rate of approximately 40%. This limited absorption characteristic should be considered when determining appropriate dosing and delivery methods to achieve therapeutic effectiveness.
Mechanism of Action
Deslanoside functions by inhibiting the Na-K-ATPase membrane pump, leading to elevated intracellular sodium and calcium levels. This increase in calcium concentration can enhance the activation of contractile proteins such as actin and myosin. Additionally, deslanoside influences the heart's electrical activity by increasing the slope of phase 4 depolarization, shortening the action potential duration, and reducing the maximal diastolic potential.
