Avadomide hydrochloride

Avadomide hydrochloride

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Avadomide hydrochloride

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Catalog Number	PR1398053456
CAS	1398053-45-6
Structure
Description	Avadomide hydrochloride is an orally active cereblon modulator. Avadomide hydrochloride modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide hydrochloride exhibits potent antitumor and immunomodulatory activities.
Synonyms	CC 122 hydrochloride
IUPAC Name	3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione;hydrochloride
Molecular Weight	322.75
Molecular Formula	C14H15ClN4O3
Canonical SMILES	O=C(N1)C(CCC1=O)N2C(C)=NC3=C(C2=O)C(N)=CC=C3.[H]Cl
InChI	InChI=1S/C14H14N4O3.ClH/c1-7-16-9-4-2-3-8(15)12(9)14(21)18(7)10-5-6-11(19)17-13(10)20;/h2-4,10H,5-6,15H2,1H3,(H,17,19,20);1H
InChI Key	BVJRNKXVSYLNFD-UHFFFAOYSA-N
Shipping	Generally, shipped at room temperature in continental US; may vary elsewhere.

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