Avadomide

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Avadomide

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Catalog Number	PR1015474324
CAS	1015474-32-4
Structure
Description	Avadomide is an orally active cereblon modulator. Avadomide modulates cereblon E3 ligase activity, inhibits NF-κB pathway, arrests the cell cycle at G1 phase, and thus induces apoptosis in cancer cell PDAC. Avadomide exhibits potent antitumor and immunomodulatory activities.
Synonyms	CC 122
IUPAC Name	3-(5-amino-2-methyl-4-oxoquinazolin-3-yl)piperidine-2,6-dione
Molecular Weight	286.29
Molecular Formula	C14H14N4O3
Canonical SMILES	O=C(C(N1C(C)=NC2=C(C(N)=CC=C2)C1=O)CC3)NC3=O
InChI	InChI=1S/C14H14N4O3/c1-7-16-9-4-2-3-8(15)12(9)14(21)18(7)10-5-6-11(19)17-13(10)20/h2-4,10H,5-6,15H2,1H3,(H,17,19,20)
InChI Key	RSNPAKAFCAAMBH-UHFFFAOYSA-N
Purity	>99%
Appearance	White to gray solid
EC Number	876-404-3
Shipping	Generally, shipped at room temperature in continental US; may vary elsewhere.
Storage Conditions	Store at 4 °C

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